For example, in a subcutaneous breast cancer xenograft mouse model, it was found that trastuzumab (an anti-HER2 antibody)-conjugated NP carrying doxorubicin was accumulated in the xenografts better than NP without antibodies, and this finding correlated with a >50% improvement in the reduction of tumor volume [7]. The gene discussed is ERBB2; the disease is breast carcinoma.