IDH1 and glioma: In addition to the further increase in the ratio of 2-HG/tCho, we found a significantly higher metabolite ratio of myo-Inositol/tCho in IDH2 gliomas (four patients with IDH2 R172K and one patient with IDH2 R172W mutations) compared to IDH1 gliomas (fifteen patients with IDH1 R132H mutation).