IFNB1 and infection: For example, blockade of IFN-β alone does not alter virus dissemination during the first 24 h following LCMV-Cl13 infection, whereas complete IFN-I signaling deficiency increases virus replication [63], indicating that despite IFN-β being produced first, IFN-α is also critical for mediating the very early antiviral effects against LCMV.