Interestingly, in the murine hyperlipidemic model, Li et al. reported that treatment with the globular domain of adiponectin enhanced eNOS phosphorylation at Ser1177, but not its expression, attenuating hyperlipidemia-induced inducible nitric oxide synthase (iNOS) expression (p < 0.05). The gene discussed is NOS2; the disease is hyperlipidemia.