Another study comparing the effects of benign Jokela type spinal muscular atrophy (SMAJ)-linked CHCHD10 G66V and the more severe ALS–FTD-associated CHCHD10 S59L showed that the accumulation of phosphorylated TDP-43 is comparable among these mutants. This evidence concerns the gene CHCHD10 and amyotrophic lateral sclerosis.