Interestingly, the immune response and autophagy-associated TBK1, Optineurin, VCP/p97, and SQSTM1/p62, which are causative genes of ALS–FTD, have been shown to be involved in PINK1-Parkin-mediated mitophagy [77,78,79]. Here, SQSTM1 is linked to amyotrophic lateral sclerosis.