A second group of parameters are modified early (D14) and remained stable at D60 (AA: methionine, proline, isoleucine, glycine, phenylalanine, lactate, urea, fructosamine, insulin, HOMA, total and HDL cholesterol), suggesting that these alterations can be very closely linked to the rapid shift from a “maintenance” diet to a “high fat high sucrose” diet but could also be considered as very early markers of a metabolic shift and/or development of insulin resistance. Here, INS is linked to Insulin resistance.