The production of type I IFNs by sentinel leukocytes, in particular that of plasmacytoid DCs that serve as a potent source of IFNs, upon viral infection initiates a type I IFN-dependent secretion of neutrophil and inflammatory monocyte chemoattractants such as IL-1α, CXCL1 and CXCL2 [61,172], highlighting the role of virus-induced type I IFNs in the regulation of neutrophil and monocyte trafficking. Here, CXCL2 is linked to viral infectious disease.