Further guidance to sites of infection is provided by a family of CXCL8 chemokines originating from concentrated sites of PAMPs and DAMPs, including CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 (IL-8), which are sensed by CXCR1 and CXCR2 on neutrophils and monocytes [74]. The gene discussed is CXCL1; the disease is infection.