In contrast, KCNMA1 is down-regulated or silenced in primary cells and in gastric carcinoma cell lines (MGC-803, BGC-823, MKN-82, SGC-7901), through hyper-methylation of its promoter, in particular, the CpG island, cg24113782 [9]. This evidence concerns the gene KCNMA1 and gastric carcinoma.