A quantitative comparison of the immune cell subpopulations in sMDI JA-0009 and the established cell line-based syngeneic standard in vivo tumor models (MC38-CEA, CT26.WT, LL/2, Clone M3, 4T1, RENCA, B16.F10) is shown in Figure 5B. The most striking difference between the newly established sMDI JA-0009 and all other formerly tested syngeneic standard models was a massive infiltration of M2 macrophages and a low T cell number, especially of CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.