Since M2 macrophages can act as anti-inflammatories due to the production of immunosuppressive factors such as IL-10, transforming growth factor β (TGFβ), or prostaglandin E2 (PGE2), and the recruitment of immunosuppressive regulatory T cells [83], immune checkpoint inhibitor treatment only moderately affected the tumor growth of JA-0009. The gene discussed is TGFB1; the disease is neoplasm.