CDKN3 and glioblastoma: Although alteration of CDKN3 gene, which encodes KAP, in the TCGA GBM dataset was not confirmed [5], KAP expression was increased, and a high KAP expression was associated with poor prognosis in a series of GBM cases [161]; however, KAP proteins expressed in GBMs were aberrantly spliced and acted dominant-negatively against wild-type KAP in the same cases [161].