Tyrosine-protein phosphatase non-receptor type 11 (PTPN11; also known as PTP-1D, PTP-2C, or SHP2) is a PTP activated mainly by RTKs and is one of the representative PTPs that have oncogenic roles in various cancers [24,33,80,81,82,83,84,85]. Here, PTPN11 is linked to cancer.