CDC25A and central nervous system cancer: Although genetic alterations of the genes encoding CDC25s are not observed in the TCGA GBM dataset, in a certain series of human glioma samples, expression of the cell-cycle marker Ki67 is increased in parallel with increased CDC25A expression, and dephosphorylation of PKM2 by CDC25A induces glycolytic metabolism, resulting in the Warburg effect and tumorigenicity of GBM cells [163,164].