Interestingly, a recent finding demonstrated PTEN is exocytically secreted by exosomes from GBM cells and suppresses Akt activity of its recipient cells in vitro [129], and exosomal microRNA (miR)-21 and miR-26a enriched in GBM patients as the circulating microRNA suppress PTEN expression [130], suggesting the profound roles of exosomes in regulation of GBMs biology via modulation of PTEN expression. This evidence concerns the gene PTEN and glioblastoma.