In GBMs, the PP6 catalytic subunit (PP6c) is overexpressed in around 0.5% of the TCGA GBM dataset [5], and siRNA knockdown of PP6c suppressed DNA-dependent protein kinase activity, resulting in an enhanced response of GBM cells to irradiation treatment in vitro and in vivo [64]. This evidence concerns the gene PPP6C and glioblastoma.