Overexpression of IKKε in glioma cells displayed decreased activity of caspase 3 but increased levels of Bcl-2, an anti-apoptotic protein, and NF-κB transactivation activity by increasing nuclear translocation of RelA and p50 proteins [99], while silencing IKKε decreased translocation [99]. The gene discussed is NFKB1; the disease is central nervous system cancer.