In the case of skeletal muscle, consisting of muscle fibers and connective and adipose tissues, previous studies suggest that activation of NF-κB primarily in the adipose tissue macrophages (ATMs) of skeletal muscle, not muscle fibers, contributes to development of insulin resistance in the context of obesity [17,18,19,20,21,22,23]. The gene discussed is NFKB1; the disease is Obesity.