Then, incubation with DHT in ovarian cancer cell lines was found to down-regulate the expression of TGFβR1/TGFβR2 at mRNA [29] and protein [27] levels as well as that of p21 protein [27], resulting in blockade of TGFβ-mediated growth inhibition [71]. The gene discussed is TGFB1; the disease is ovarian carcinoma.