NCOA3 and ovarian cancer: By contrast, in primary cultures derived from ovarian cancer, DHT was shown to reduce the expression levels of NCOA3 (in 5 of 8 primary cultures; up-regulated in 2 primary cultures) as well as SRC-1 (in 3 of 8 primary cultures; no significant changes in others), while the levels of NCOA3 (but not SRC-1) were approximately 2-fold higher in ovarian cancers than in primary cultures of ovarian surface epithelium [71].