SQSTM1 and Alzheimer disease: Post-mortem electron-microscopy and immunoblotting analysis of AD patient brains show that dystrophic neurons containing neurofibrillary tangles also evidence a high number autophagosomes filled with electron-dense material [71,72]; the amount of insoluble ubiquitinated proteins in conjunction with sequestrosome 1/p62 (SQSTM1/p62) is also significantly increased in AD patient brains when compared with age-matched controls, and positively correlates with the density of extracellular amyloid plaques [15,73,74].