MRE11 and cancer: Indeed, in this region, there are 4 genes that deserve to be reported: 2 of these are known to be tumor suppressors, HTATIP2 (involved in metastasis suppression in several tumors) and WT1 (whose deletion is associated with nephroblastoma in children); the other 2, MRE11 and ATM, have been reported to be involved in DNA repair mechanisms; thus, their loss of function may lead to defective DNA repair, which in turn, leads to cancer [27,28,29].