The epithelial‐mesenchymal transition (EMT) significantly contributes to the CRC development because normal intestinal epithelial cells can be vested with the malignant phenotypes during this process.15 In this study, we observed that miR‐487b could inhibit EMT morphology alterations of CRC cells, strengthen CDH1 and suppress Vimentin at the mRNA and protein levels both in vitro and in vivo. Here, VIM is linked to colorectal carcinoma.