SPHK1 and breast cancer: In particular, SPHK1 plays an oncogenic role in promoting survival and invasion in some tumors.14 High SPHK1 expression promoted breast cancer cell proliferation and invasion, which were associated with poor overall survival.15 Additionally, SPHK1 participated in cisplatin and docetaxel resistance in gastroesophageal cancer.16 However, little is known about the role of SPHK1 in tumor stroma cells.