As the results shown in Figure 2D, the CCI was negatively correlated with mutations of driver genes including TP53 in BRCA, LIHC, and LUAD, XIRP2 in STAD, MUC4 in KIRC and FAM46C in HNSC, while negatively correlations were observed for RNF43 in CESC, PIK3CA in BRCA, FRG1 in HNSC, and EGFR in BLCA. This evidence concerns the gene RNF43 and bladder transitional cell carcinoma.