KRAS and cancer: KRAS mutations have been shown to be associated with poor prognosis in cancer patients, including CRC and KRAS status is an independent prognostic factor for OS and PFS.54, 60 cfDNA KRAS mutations are also reported to be predictors of poor prognosis for mCRC.36 So far, 7 out of 8 studies revealed poor prognostic potential of KRAS mutations in blood in terms of OS.