Applied to the detection of gene fusions and to the differential expression, it has elucidated potential biomarkers and previously unknown biology in combination with DNA sequencing.18, 19 In this way, exome sequencing uncovered mutations in kelch‐like ECH‐associated protein 1 (KEAP1) in ≈20% of lung adenocarcinomas,20 while matching RNA sequencing revealed a constitutively activated transcriptional response of 27 genes as a potential biomarker signature for KEAP1 mutant tumors.21 The gene discussed is KEAP1; the disease is lung adenocarcinoma.