Human emphysema and COPD have been associated with induction of cellular senescence (Chilosi, Carloni, Rossi, & Poletti, 2013; Tsuji et al., 2006), and therefore, we asked the question of whether TLR4 deficiency‐mediated emphysema was also associated with cellular senescence. Here, TLR4 is linked to chronic obstructive pulmonary disease.