We proceeded to generate mice that express the human TLR4 (hTLR4) transgene, in the presence of DOX, only in Ec (Ec‐TLR4‐reconstit) to confirm the role of Ec TLR4 in modulating age‐related emphysema in TLR4 ‐/‐ mice. Here, TLR4 is linked to pulmonary emphysema.