SPAST and nervous system disorder: Among these, due to being a member of ELAV-like (Hu) protein family, which is involved in neuronal development and differentiation, neurological disorders, and neuron-specific expressions [49]; HuR was chosen to be analyzed for its effect on post-transcriptional regulations of KATNA1 and SPG4. Also, it was previously suggested that HuR is able to enhance translational repression due to binding to cis-acting elements present in the 5’ UTR of p27 encoded by CDKN1B gene, therefore HuR is an important factor to control cell proliferation by decreasing the level of cell cycle inhibitor [50,51].