ICAM1 and colorectal carcinoma: Previous studies showed that the Gegen San containing Ge Hua, Ge Gen, and Guan Zhong had a significant inhibitory effect on the cancer tissues of CRC nude mice, it could significantly promote the apoptosis of tumor cells [10], decrease the expression of ICAM-1, and regulate the number of regulatory T cells in the liver microenvironment in the case of CRC liver metastasis [11,12].