In the current study, we found that after 10 weeks the AMI group showed reduced levels of serum netrin-1 and reduced expression of netrin-1 protein and DCC receptors in myocardial tissues, whereas the ET group showed significantly increased expression of myocardial netrin-1 protein, DCC receptors and increased levels of serum netrin-1. The gene discussed is NTN1; the disease is essential thrombocythemia.