Our previous studies have shown that VGLL4 could bind with TEAD4 through its TDU domains and directly competed with YAP for binding to TEAD4, which result in significantly suppressing cell growth in gastric and lung cancer cell lines with decreased expression of YAP/TEAD downstream genes including CTGF and CYR61, whereas deletion of both TDU domains attenuated the inhibitory function [14–16]. The gene discussed is VGLL4; the disease is lung cancer.