Additionally, Apoptosis-stimulating of p53 protein 2 (TP53BP2) could specifically regulate p53-dependent apoptosis and could be down-regulated with the micro RNA miR-548d-3p by directly targeting the 3′ UTR of the protein, showing that the miR-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells [26]. The gene discussed is TP53; the disease is breast carcinoma.