With more effective oral ADP receptor antagonists than clopidogrel, such as prasugrel or ticagrelor, there is no evidence of reduced efficacy in patients with DM who present with acute coronary syndromes or long‐term post‐MI.14, 35, 36 In particular, some of the concerns regarding the efficacy of aspirin are related to short plasma residence time of the drug, while there is accelerated platelet generation during the 24‐hour cycle. Here, P2RY1 is linked to acute coronary syndrome.