RYR1 and rhabdomyolysis: Patient 34, who suffered from a severe episode of heat- and exercise-induced rhabdomyolysis with severe encephalomyelopathy, resulting in a permanent spinal cord lesion, had two RYR1 variants on separate alleles [c.2488C > T (p.Arg830Trp),c.10219G > A (p.Ala3407Thr)].