Along the same lines, it is arguable that even some of the histopathological features considered to be non-specific, increase of internal or even central nuclei, increased fibre size variability, and type 1 fibre predominance may represent minor manifestations of well-recognized RYR1-related congenital myopathies [3, 4, 57]. This evidence concerns the gene RYR1 and congenital myopathy.