EZH2 and HIV-1 infection: To investigate whether MALAT1-promoted HIV-1 infection was due to the antagonism of EZH2-mediated silencing of viral gene transcription, we further knocked down EZH2 expression with specific shRNA in MALAT1-stably-knocking-out HEK293T cells (Figure 5A and B), and then infected cells with HIV-luc/VSV-G for an additional 24 h.