Since in Southern and eastern Indian population CYP1B1 is involved in the pathogenesis of POAG, there was a need for screening of North Indian POAG patients for common mutations in CYP1B1. The direct costs, such as the cost of its diagnosis and treatment, and the indirect costs involved exert a heavy burden on both the patients and their families [29]. The gene discussed is CYP1B1; the disease is open-angle glaucoma.