Through Logistic single factor analysis of risk factors associated with liver cirrhosis complicated with SBP, it was found that Child-Pugh classification (P=0.001), serum CRP (P=0.005), ascites WBC (P=0.001), ascites ALB (P=0.001), upper gastrointestinal hemorrhage (P=0.001), hepatorenal syndrome (P=0.002), hepatic encephalopathy (P=0.001) and hyponatremia (P=0.001) in patients were related to the occurrence of SBP (Table 3). The gene discussed is CRP; the disease is hepatorenal syndrome.