The expression of adiponectin was decreased in preeclampsia, and expression of p–p38 was increased, which was negatively correlated with adiponectin expression (r=−0.413, P<0.05), while the expression level of p-STAT5 was decreased, which was positively correlated with adiponectin expression (r=0.526, P<0.05). The gene discussed is ADIPOQ; the disease is preeclampsia.