Immune stimulatory therapies such as oncolytic viruses have been shown to improve responses to anti-PD-1 mAbs by enhancing T lymphocyte infiltration into the tumor microenvironment (124), therefore combining DC vaccination with targeting of CD27 and LAG-3 is predicted to have a similar effect via enhanced antigen-specific priming with CD27 agonism or enhanced DC migration and antigen presentation with LAG-3. This evidence concerns the gene PDCD1 and neoplasm.