Sipuleucel-T is manufactured by density gradient enrichment of peripheral blood mononuclear cells (PBMC) loaded with prostatic acid phosphatase (PAP) peptide fused to GM-CSF (9), whilst Rocapuldencel-T is manufactured with monocyte-derived dendritic cells (MoDC) loaded with tumor neo-antigens in the form of mRNA (10). This evidence concerns the gene ACP3 and neoplasm.