Nonetheless, the activation of EMAPII by hypoxia remains controversial: although the upregulation of this factor in response to hypoxia has been usually described, there is a study that reports its downregulation in hypoxia-treated uveal melanoma cells (48) and, in addition, other studies have reported that the regulation of this mediator by hypoxia is more likely exerted at the translational or post-translational level (56). This evidence concerns the gene AIMP1 and uveal melanoma.