BRAF and metastatic melanoma: In the multicenter, randomized controlled, open label, phase III trial conducted by Weber et al. (CheckMate 037), patients with unresectable or metastatic melanoma that had disease progression on ipilimumab (or ipilimumab plus a BRAF inhibitor if they had BRAF V600E mutation) were recruited at 90 sites in 14 different countries [18].