A number of candidates with known links to AD were identified, including low affinity immunoglobulin gamma Fc region receptor II-b (Fcgr2b) (Kam et al., 2013), as well as candidates not well studied in the context of aging or AD, including G-protein coupled estrogen receptor 1 (Gper1) (Briz et al., 2015), both validating our approach and identifying novel candidates that likely contribute to disease onset. The gene discussed is GPER1; the disease is Alzheimer disease.