Like in the case of the α4β1 integrin, CCR7 overexpression in CLL cells correlates with the presence of lymphadenopathy, and an anti-CCR7 monoclonal antibody inhibits in vitro CLL cell migration and induces complement-dependent cytotoxicity against CLL cells (56, 161, 162). Here, CCR7 is linked to B-cell chronic lymphocytic leukemia.