Additionally, Zucchetto et al. (151) showed that CCL3 and CCL4 are overexpressed in CD49d+/CD38+ CLL cells (poor prognosis), compared to CD49d−/CD38− CLL cells, and that ligand engagement of CD38 upregulated both chemokines in the double positive cells. This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.