CXCL12 and B-cell chronic lymphocytic leukemia: Besides ulocuplumab and plerixafor, other monoclonal antibodies or small molecule antagonists to CXCR4, such as BL-8040 and PF-06747143 have been shown to inhibit the CXCL12/CXCR4-mediated migration of CLL cells (222) (Figure 2).