FOXP3 and inflammatory bowel disease: Instead, we have shown that type-1 like (Tr1-like, i.e., IL-10-secreting, Foxp3-negative) Treg, characterized by a double positive CD4CD8α (DP8α) phenotype, are abundant in the healthy human colon, circulate in blood, and are decreased in inflammatory bowel disease (IBD) patients in both compartments.