Instead, we have shown that type-1 like (Tr1-like, i.e., IL-10-secreting, Foxp3-negative) Treg, characterized by a double positive CD4CD8α (DP8α) phenotype, are abundant in the healthy human colon, circulate in blood, and are decreased in inflammatory bowel disease (IBD) patients in both compartments. The gene discussed is IL10; the disease is inflammatory bowel disease.