(118) examined the effect of (R)- and (S)-ketamine on Alanine, Serine, Cysteine Transporter 2 (ASCT2)-mediated transport of D-serine in adrenal pheochromocytoma PC-12 and human neural astrocytoma 1321N1 cells, and primary neuronal cells in culture and reported that (S)-ketamine decreased cellular export by selectively inhibiting ASCT2; the authors suggested that this interaction might represent a source of dissociative effects seen with (R,S)-ketamine. This evidence concerns the gene SLC1A5 and adrenal gland pheochromocytoma.