In their SR knockout mouse model (58), Balu and Coyle (59) observed reduced binding of cyclic adenosine monophosphate (cAMP)-responsive element binding (CREB) to the promoter regions of genes for three molecules implicated in the pathophysiology of schizophrenia, namely brain-derived neurotrophic factor (BDNF), microRNA-132, and Arc (60). This evidence concerns the gene BDNF and schizophrenia.