PRRT2 and Hypertension: The present results showing a protein kinase-mediated regulation of Ca2+ handling linked to the α1-adrenoceptor in resistance arteries suggest that changes in PI3K, MAPK, and PKC signaling pathways involving enhanced Ca2+ mobilization not coupled to contraction, might participate in the changes toward a VSM proliferative phenotype and be involved in vascular remodeling in hypertension and other insulin resistant states.