In support of sirolimus as a suitable treatment option in SLE, blockade of the mTOR pathway has shown promising effects in lupus animal models (Warner et al., 1994; Bonegio et al., 2005; Lui et al., 2008) as well as in patients (Fernandez et al., 2006; Yap et al., 2012, 2018; Lai et al., 2013; Bride et al., 2016; Herold et al., 2018). The gene discussed is MTOR; the disease is systemic lupus erythematosus.