Additionally, the role of the downregulation of DREAM as part of an endogenous neuroprotective mechanism that improves ATF6 processing, neuronal survival in the striatum, and motor coordination in R6/2 mice, a model of Huntington’s disease (HD), has been recently described (Naranjo et al., 2016; López-Hurtado et al., 2018). This evidence concerns the gene ATF6 and Huntington disease.