Alterations in the function of the complexes KV4/KChIP and/or DREAM are implicated in different neuronal pathologies such as Alzheimer’s (Hall et al., 2015) and HD (Naranjo et al., 2016), spinocerebellar ataxia (Smets et al., 2015) or epilepsy (Villa and Combi, 2016). Here, KCNIP3 is linked to Huntington disease.