Alterations in the function of the complexes KV4/KChIP and/or DREAM are implicated in different neuronal pathologies such as Alzheimer’s (Hall et al., 2015) and HD (Naranjo et al., 2016), spinocerebellar ataxia (Smets et al., 2015) or epilepsy (Villa and Combi, 2016). The gene discussed is KCNIP3; the disease is cerebellar ataxia.