Knockdown of NR1H4 can also attenuate the expression level of SOCS1 and SOCS2 after ZINC24469384 treatment, and the decrease of SOCS2 is sharper than SOCS1 (Fig. 7D), These data indicated that SOCS2 may play more important role in NR1H4 induced anti-tumor effects. This evidence concerns the gene SOCS1 and neoplasm.