Although promoter AP-1 motifs are overall less predictive of strong HSC gene induction than ETS1 and RUNX1 motifs, AP-1 may convey growth factor signals to NASH- and proliferation-associated genes in and beyond cluster 6 and together with ETS1 account for the full effects of MEK/ERK inhibition. This evidence concerns the gene RUNX1 and metabolic dysfunction-associated steatohepatitis.