This together with the nuclear localization of ETS1 in activated HSCs of NASH livers and the attenuation of HSC activation by ETS1 and RUNX1 knockdown or MEK inhibition denotes a conserved MEK-ERK-ETS1-RUNX1 signaling axis promoting HSC transcriptional plasticity and activation in NASH. Here, MAP2K7 is linked to metabolic dysfunction-associated steatohepatitis.