The top ten signaling pathways included: Systemic lupus erythematosus; Alcoholism; Viral carcinogenesis; Complement and coagulation cascades; Hematopoietic cell lineage; Primary immunodeficiency; Cell cycle; ECM-receptor interaction; Bladder cancer; PPAR signaling pathway; p53 signaling pathway; Transcriptional misregulation in cancer; Pertussis; Mineral absorption (Fig. 5). This evidence concerns the gene PPARA and alcohol drinking.