Recent studies conducted in ovarian and lung cancer cell lines showed that IL-8 signaling transactivates the epidermal growth factor receptor and activates downstream mitogen activated protein kinase (MAPK) signaling by mediating the growth factor receptor binding protein2/SOS-promoted activation of monomeric small G-protein, Ras-GTPase25. The gene discussed is CXCL8; the disease is lung carcinoma.