Therefore, using the method of tag SNPs combined with recent research reports, we detected six SNPs in the TRIB1 (rs2954029, rs2980880 and rs10808854) and TRPS1 (rs231150, rs2737229 and rs10505248), their G × G and G × E interactions on serum lipid levels, the risk of CHD and IS in a Southern Chinese Han population. The gene discussed is TRIB1; the disease is coronary artery disorder.