APOB and Combined hyperlipidemia: In addition, studies in vivo mouse have showed that overexpression of TRIB1 causes decrease of serum TC, TG, LDL, very-low-density lipoprotein (VLDL), and ApoB levels35 and that inactivation of TRIB1 results in mixed hyperlipidemia by increasing hepatic lipogenesis and VLDL secretion35.