In addition, studies in vivo mouse have showed that overexpression of TRIB1 causes decrease of serum TC, TG, LDL, very-low-density lipoprotein (VLDL), and ApoB levels35 and that inactivation of TRIB1 results in mixed hyperlipidemia by increasing hepatic lipogenesis and VLDL secretion35. This evidence concerns the gene TRIB1 and Combined hyperlipidemia.