We also examined whether genetic associations with asthma overlap with atopy by testing lead SNPs from Table 2 for association with total serum IgE (tIgE) using 4132 subjects for whom this phenotype was available (CAAPA lead SNPs and lead SNPs from TAGC that replicated in CAAPA; associations were tested separately in cases and controls and then combined using meta-analysis). Here, IGHE is linked to asthma.