To test if the IFNγ signaling pathway could be a novel marker of low infection risk in vaccinees, we built a logistic regression model combining gender, behavior risk and previously described correlates of risk (IgA against Env, IgG against V1/V2, DQB1*06 allele, DPB1*13 allele, and PFS) to predict acquisition of HIV-1 among RV144 vaccinees. Here, HLA-DPB1 is linked to infection.