MC1R and melanoma: The preventative effect of ML349 on melanomagenesis in redheads was validated using our previously generated MC1R RHC variant mice (Tyr-Cre-BRAFCA/C57BL/6J-MC1Re/eJ/MC1RR151C-Tg) that were given a dose of 500 J/m2 UVB irradiation each week for 4 weeks and then observed for melanoma incidence for another 90 days.