To testify the expression of MALAT1, miR-15b-5p and MAPK1, qRT-PCR was performed and the results illustrated that MALAT1 and MAPK1 expression in CAD blood samples and EPCs were significantly up-regulated while miR-15b-5p was conspicuously down-regulated (P<0.01, Figure 4A). The gene discussed is MAPK1; the disease is coronary artery disorder.